- Define and develop Next Generation Sequencing (NGS) analysis pipelines for quantifying CRISPR based on-target and off-target events as well as algorithms for computational prediction of guide RNA specificity and efficiency
- Routinely, analyze and interpret NGS sequencing data to determine gene editing efficiencies and off-target events
- Work closely with colleagues in the experimental team performing CRISPR experiments to communicate results or advise on appropriate bioinformatic analyses
- Troubleshoot and optimize, both independently and in collaboration with colleagues
- Participate in regulatory interaction meetings, provide responses to questions from regulators, and strategically communicate off-target characterization results
- Degree (Ph.D., or M.S. with 6+ years of relevant experience) in computational biology/bioinformatics or related field
- Background in molecular biology, particularly gene editing with relevant experience in academic or industrial setting
- Experience in developing computational pipelines to analyze NGS datasets, including genome/exome sequencing data and/or targeted DNA sequencing
- Experience in developing and maintaining pipelines for CRISPR-Cas analysis (e.g. GUIDE-Seq, SITE-Seq, Amp-Seq)
- Confidence in use of common bioinformatics tools for NGS data analysis (e.g. BWA, BEDtools, GATK, IGV) and public omics databases (e.g. gnomAD, TCGA)
- Proficiency with Python and/or R is essential; familiarity with other languages such as Perl, C++ and MATLAB would be a plus
- Strong understanding of CRISPR-Cas technology
- Experience with designing guide RNA and in silico assessment of on/off-target activity
- Familiarity with Illumina sequencing platforms and NGS library preparation methods
- Experience in analysis of single cell sequencing data (e.g. single cell DNA sequencing, MissionBio)
- Proficiency with handling large-scale genomics data in a Linux environment
- Experience with front-end web development (e.g. HTML/CSS/Javascript, bootstrap and/or R Shiny) is considered a plus
- Strong communications skills (written and oral)
- Attention to detail and problem-solving skills, strong communication skills, and the ability to work in a team
Company
Location
Basel - Switzerland
Job type
Full-Time
JavaScript Job Details
EINFÜHRUNG:
For our client an applied gene editing, cellular, and immunotherapy company located in Basel, we are looking for an individual as
For our client an applied gene editing, cellular, and immunotherapy company located in Basel, we are looking for an individual as
(Senior) Scientist, Computational Biology – NGS
(Permanent employment, fulltime). The earliest start date is as soon as possible.AUFGABENBESCHREIBUNG:
ERFORDERLICHES PROFIL:
Interested? You can find more information here:
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